Hoeksema is the Director of Government and Public Affairs for the Population Association of America and the Association of Population Centers. In this capacity, she lobbies Congress and the Administration, urging support for funding the National Institutes of Health, National Science Foundation, US Agency for International Development, and a number of federal statistical agencies, including the U.S. Census Bureau.
She previously held several senior positions at the National Institutes of Health from 1995-2004, including Legislative Analyst for the National Center for Complementary and Alternative Medicine where she responded to congressional inquiries, analyzed proposed legislation, and briefed Members of Congress and their staff.. She is a member of the Steering Committee of the Ad Hoc Group for Medical Research Funding, Executive Committee of the Friends of the National Institute of Child Health and Human Development, Executive Committee of the Friends of the National Institute on Aging, and a member of the Wolf Trap National Park for the Arts Associates Board of Directors.